Abolishing CDK4/six kinase activity and subsequent reactivation of Rb in these tumors is shown to inhibit tumor initiation and growth. Here We are going to describe LEE011- an orally bioavailable, selective little molecule inhibitor of CDK4/6 kinases. LEE011 inhibits CDK4/6 kinase action with nM IC50 and is very selective for https://torin102345.tokka-blog.com/17255352/the-basic-principles-of-asp2215