This mechanism might be through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical response to doxycycline must be monitored intently. Phenytoin, sodium valproate, valproic acid: The impact of barbiturates on the metabolism of phenytoin appears to generally be variable. https://josefah432uhs6.blog5star.com/profile