TAK-243 preferentially sure to UBA1 over the similar E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished amounts of ubiquitylated proteins, improved markers of proteotoxic anxiety and DNA damage anxiety. In vivo, TAK-243 decreased leukemic load and qualified leukemic stem cells with out https://charlesj318afj1.newbigblog.com/profile