You will find a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to lessen afferent discomfort transmission and create analgesia. For that reason, medication like clonidine that focus on alpha-two receptors can affect the transmission of suffering. Applies to clonidine: https://conani035jfa4.wikipowell.com/user